THE NEUROGENIC PROGRAM IN THE TREATMENT OF NEURO-DEGENERATIVE DISORDERS.
John Grinstein Ph.D..
Food Biochemistry Research UK.
Since we first published, in November 2002, the 6 stages on which our Neurogenic Program is based, we have received hundreds of requests, from all over the world, asking us how the medicinal extracts RG-40 and GCRF can be obtained. (Full text of the 2002 Neurogenic Diet, can be found at www.shydrager.com
The RG-40 and the GCRF are medicinal extracts that are produced from organic vegetable sources, mainly selected fruit and vegetables, that have been around for thousand of years.
That is why, during the 15 years or more that these 100% natural preparations have been used, they have never produced any form of adverse reaction or side effect.
For a purely organic extraction, to reach the high stages of enrichment needed to produce significant medicinal results, the use of very large amounts of plant sources are required. It then becomes too expensive and too hard to produce, to manufacture them on a large scale or for commercial use.
However, when these extracts are used within the framework of the Neurogenic Program, it justifies the effort involved in producing them. The results they produce are much more significant than merely alleviating the symptoms of a human disease.
The RG-40 and GCRF, when used in the context of the Neurogenic Program, are demonstrating that some areas of the human brain, which have been previously damaged or became dormant, can regenerate and restore their previous neuronal activity.
There is then obviously a real incentive to support and sponsor the provision of these medicinal extracts, because their research projects are demonstrating that the ageing process of the human brain, can somehow be modulated.
Almost every theory of ageing today agrees that neuronal chemistry is what governs the main biological ageing clocks.
In Part, of this Newsletter, we will try to define and explain how our Neurogenic Program works. In Part 2, we will present details of cases in which the neurogenic program has already produced some very important results.
In this newsletter we will try to explain why patients, who followed faithfully the recommendation of our neurogenic diet, were able to find that their MSA or their Parkinsonian symptoms had gradually disappeared.
The main differences between the neurogenic diet and all other drugs and medicines to treat Parkinsonís Disease (PD) today, are the following:
1.- With the Neurogenic Diet, patients gradually require the prescribed PD drugs, less times per day, in order to be able to perform their daily activities.
With the PD drugs, patients have to gradually increase the number of times per day they take their drugs, in order to be able perform their daily activities.
2.- With the Neurogenic Diet, patients find out that every month, they can decrease the level of the drugs they have been prescribed.
For example, if they required a dose of one tablet of Sinemet of 200 mg Dopa/50 mg Carbidopa, in order to get a proper 3 hours ON period, when following the Neurogenic Diet, they can get the same 3 hours of ON period, when taking only half of the potency of Sinemet. That is, they require one Sinemet of 100 mg Dopa/25 mg Carbidopa.
3.- It is important to maintain the use of Sinemet at a regular low level, because when Sinemet is used more than 3 times per day, it will rapidly create the a need of increasing it to 5 times a day, then to 7, and then to 12 or more.
When Sinemet is taken more than 3 times per day, the endogenous (self production) of dopa and dopamine in cells and neurons in the brain, starts to become inhibited.
The more times per day a patient takes Sinemet, the more the self synthesis of dopamine is inhibited. The patient becomes more and more dependent on an external source of L-Dopa.
With time, the self synthesis of these transmitters in cells and neurons in the brain, becomes atrophied.
In the same way as an athlete who does not practice, atrophies the ability of his muscles, or a person who had an accident and remains in a wheelchair atrophies his muscles, instead of exercising to reactivate them.
4.- When Sinemet needs to be taken 5 or 10 times a day or more, it alters from being, the most efficient drug to treat Parkinsonís disease, into the originator of a number of intolerable adverse reactions and side effects.
These adverse reactions are usually not noticeable, when a PD patient is using Sinemet no more than 2 or 3 times a day.
5.- Can then we maintain Sinemet at a maximum of 3 times a day during the whole course of the disease?. Unfortunately this is almost impossible, because of the chemistry of dopamine synthesis in the brain.
The more that an external source of L-Dopa is introduced into the system, the less L-Dopa that is produced within the system.
The above, is important to understand, so we will try to explain it in easy terms.
The brainís dopamine chemistry works as follows:
a.- Tyrosine is an amino acid present in almost all foods. In normal subjects, part of the tyrosine taken as food, is converted to L-Dopa. In Parkinsonís Disease this enzymatic process is defective.